In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

Specialized peripheral sensory neurons known as nociceptors alert us to potentially
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …

Capsaicin, the main pungent ingredient in 'hot'chilli peppers, elicits a sensation of burning
pain by selectively activating sensory neurons that convey information about noxious stimuli …

Pain-producing heat is detected by several classes of nociceptive sensory neuron that differ
in their thermal response thresholds,,. The cloned capsaicin receptor, also known as the …

With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …

Abstract The vanilloid receptor-1 (VR1) is a ligand-gated, non-selective cation channel
expressed predominantly by sensory neurons. VR1 responds to noxious stimuli including …

The integrity of mitochondrial function is fundamental to cell life. It follows that disturbances
of mitochondrial function will lead to disruption of cell function, expressed as disease or …

Chili peppers produce the pungent vanilloid compound capsaicin, which offers protection
from predatory mammals. Birds are indifferent to the pain-producing effects of capsaicin and …

ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation
when released from damaged tissue1-10. Here we report the molecular cloning and …