Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

Sleep plays an important role in maintaining neuronal circuitry, signalling and helps
maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian …

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …

The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have
not been documented. Here we used PET and 18F-florbetaben to measure brain Aβ burden …

See Mander et al.(doi: 10.1093/awx174) for a scientific commentary on this article. Sleep
deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote …

Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and
can profoundly affect health. Accumulating evidence indicates that circadian and sleep …

Importance Circadian rhythm disturbances occur in symptomatic Alzheimer disease (AD)
and have been hypothesized to contribute to disease pathogenesis. However, it is unknown …

Sleep is implicated in cognitive functioning in young adults. With increasing age, there are
substantial changes to sleep quantity and quality, including changes to slow-wave sleep …

Disturbances in the sleep–wake cycle and circadian rhythms are common symptoms of
Alzheimer Disease (AD), and they have generally been considered as late consequences of …