Sleep has a major role in learning, memory consolidation, and metabolic function. Although
it is known that sleep restriction increases the accumulation of amyloid β peptide (Aβ) and …

INTRODUCTION Measuring day‐to‐day sleep variability might reveal unstable sleep‐wake
cycles reflecting neurodegenerative processes. We evaluated the association between …

Associations of sleep characteristics with mild cognitive impairment (MCI) have been
examined in cross-sectional, but rarely in longitudinal studies. Incident MCI and sleep …

Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by
progressive hippocampal-dependent explicit memory deficits that begin at the onset of the …

Sleep represents an active phenomenon regulated by a highly integrated network of cortical
and subcortical structures. This complex model results in disruptions at various levels during …

Highlights•Human genetics offers essential insight into the characterization of sleep.•Genetic
polymorphisms impact sleep timing, duration, and architecture.•A bi-directional relationship …

Background: Emerging evidence indicates that sleep disorders are the common non-
cognitive symptoms of Alzheimer's disease (AD), and they may contribute to the …

Sleep deprivation (SD) is the hallmark of modern society and may increase risk of
Alzheimer's disease (AD). However, it is unclear how SD facilitates early cognitive …

Currently, over 44 million people worldwide suffer from Alzheimer's disease (AD). A common
feature of AD is disrupted sleep. Sleep is essential for many psychological and physiological …

Most therapeutic agents are designed to target a molecule or pathway without consideration
of the mechanisms involved in the physiological turnover or removal of that target. In light of …