CD8+ T cell metabolism in infection and cancer
M Reina-Campos, NE Scharping… - Nature Reviews …, 2021 - nature.com
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …
malignant cells and can provide long-term protective immunity. In the response to infection …
Meta-analysis of leukocyte diversity in atherosclerotic mouse aortas
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments
Tissue-resident memory T cells (TRM cells) provide protective immunity, but the
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …
Metabolic programs of T cell tissue residency empower tumour immunity
Tissue resident memory CD8+ T (TRM) cells offer rapid and long-term protection at sites of
reinfection. Tumour-infiltrating lymphocytes with characteristics of TRM cells maintain …
reinfection. Tumour-infiltrating lymphocytes with characteristics of TRM cells maintain …
Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses
Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory
B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper …
B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper …
Innate lymphoid cells: diversity, plasticity, and unique functions in immunity
M Colonna - Immunity, 2018 - cell.com
Type 1, 2, and 3 innate lymphoid cells (ILCs) have emerged as tissue-resident innate
correlates of T helper 1 (Th1), Th2, and Th17 cells. Recent studies suggest that ILCs are …
correlates of T helper 1 (Th1), Th2, and Th17 cells. Recent studies suggest that ILCs are …
Heterogenous populations of tissue-resident CD8+ T cells are generated in response to infection and malignancy
Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous
surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and …
surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and …
Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts
Memory CD8+ T cells can be broadly divided into circulating (T CIRCM) and tissue-resident
memory T (T RM) populations. Despite well-defined migratory and transcriptional …
memory T (T RM) populations. Despite well-defined migratory and transcriptional …
Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing
During an immune response to microbial infection, CD8+ T cells give rise to distinct classes
of cellular progeny that coordinately mediate clearance of the pathogen and provide long …
of cellular progeny that coordinately mediate clearance of the pathogen and provide long …
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells
Adoptive T cell therapies (ACTs) hold great promise in cancer treatment, but low overall
response rates in patients with solid tumors underscore remaining challenges in realizing …
response rates in patients with solid tumors underscore remaining challenges in realizing …