Immunological memory and exhaustion are fundamental features of adaptive immunity.
Recent advances reveal increasing heterogeneity and diversity among CD8 T-cell subsets …

CD8+ T cell immunological memory of past antigen exposure can confer long-lived
protection against infections or tumors. The fact that CD8+ memory T cells can have features …

Tissue-resident-memory CD8+ T cells (TRM) have been described as a non-circulating
memory T cell subset that persists at sites of previous infection. While TRM in all non …

Background and Aims The diverse inflammatory response found in the liver of patients with
autoimmune hepatitis (AIH) is well established, but identification of potentially pathogenic …

Historically, the gold-standard benchmark for vaccine immunogenicity has been the
induction of neutralizing antibodies detectable in the serum of peripheral blood. However, in …

Memories of previous immune events enable barrier tissues to rapidly recall distinct
environmental exposures. To effectively inform future responses, these past experiences …

The unique environment of the lungs is protected by complex immune interactions. Human
lung tissue-resident memory T cells (TRM) have been shown to position at the pathogen …

T cell activation, a key early event in the adaptive immune response, is subject to elaborate
transcriptional control. In the present study, we examined how the activities of eight major …

During acute infections, CD8+ T cells form various memory subpopulations to provide long-
lasting protection against reinfection. T central memory (TCM), T effector memory (TEM), and …

In response to infection, pathogen-specific CD8 T cells differentiate into functionally diverse
effector and memory T cell populations critical for resolving disease and providing durable …