Background Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with
high morbidity and mortality. Effective treatments for IPF are limited. Several recent studies …

Transforming growth factor-β s (TGF-β) regulate a wide variety of cellular functions in normal
development and are involved in both tissue homeostasis and disease pathogenesis. The …

Background Idiopathic pulmonary fibrosis is a fatal disease for which no effective treatment
exists. We assessed whether treatment with interferon gamma-1b improved survival …

1. INTRODUCTION 1.1 An overview of the ILD guideline Since the publication of the first
BTS guidelines for diffuse lung disease nearly 10years ago, 1 the specialty has seen …

Background: Galectin-β is a p-galactoside-binding protein which is implicated in diverse
physiological and pathological processes including human liver cirrhosis and a mouse lung …

Fibrosis affects multiple organs and is associated with hyperproliferation, cell
transdifferentiation, matrix modification and contraction. It is therefore essential to discover …

Abstract Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, and often fatal form of
interstitial lung disease. It is characterized by injury with loss of lung epithelial cells and …

IFN-γ production by T cells is pivotal for defense against many pathogens, and the proximal
promoter of IFN-γ,− 73 to− 48 bp upstream of the transcription start site, is essential for its …

Interstitial lung disease (ILD) in infants and children represents a heterogeneous group of
respiratory disorders that are mostly chronic and associated with high morbidity and …

Idiopathic pulmonary fibrosis (IPF) is a poorly understood disease that usually leads to death
within 5 years of diagnosis. Despite our better understanding of IPF pathogenesis, the …