One of the most important scientific discoveries of recent years was the disclosure that the
intestinal microflora takes part in bidirectional communication between the gut and the brain …

Biochemical and neuropathological studies of brains from individuals with Alzheimer
disease (AD) provide clear evidence for an activation of inflammatory pathways, and long …

Alzheimer's disease (AD) pathology is thought to progress from normal cognition through
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …

Gut microbiota has a proven role in regulating multiple neuro-chemical pathways through
the highly interconnected gut-brain axis. Oral bacteriotherapy thus has potential in the …

Mutant isocitrate-dehydrogenase 1 (mIDH1) synthesizes the oncometabolite 2-
hydroxyglutarate (2HG), which elicits epigenetic reprogramming of the glioma cells' …

Periodontal disease (PD) is a complex and infectious illness that begins with a disruption of
bacterial homeostasis. This disease induces a host inflammatory response, leading to …

Rationale: Increasing evidence indicates that alterations of the cerebral microcirculation may
play a role in Alzheimer disease, the leading cause of late-life dementia. The amyloid-β …

The current clinical trial landscape targeting Alzheimer's disease (AD) is reviewed in the
context of studies completed from 2019 to 2021. This review focuses on available data for …

The identification of microglia-associated, neurological disease-causing mutations in
patients, combined with studies in mouse models has highlighted microglia, the brain's …

Alzheimer′ s disease (AD) is characterized by deposition of amyloid plaques,
neurofibrillary tangles, and neuroinflammation. In order to study microglial contribution to …