Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy
Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear
envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery …
envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery …
Jamming in embryogenesis and cancer progression
E Blauth, H Kubitschke, P Gottheil, S Grosser… - Frontiers in …, 2021 - frontiersin.org
The ability of tissues and cells to move and rearrange is central to a broad range of diverse
biological processes such as tissue remodeling and rearrangement in embryogenesis, cell …
biological processes such as tissue remodeling and rearrangement in embryogenesis, cell …
Cell–matrix and cell–cell interaction mechanics in guiding migration
Physical properties of tissue are increasingly recognised as major regulatory cues affecting
cell behaviours, particularly cell migration. While these properties of the extracellular matrix …
cell behaviours, particularly cell migration. While these properties of the extracellular matrix …
The cancer microenvironment: mechanical challenges of the metastatic cascade
The metastatic cascade presents a significant challenge to patient survival in the fight
against cancer. As metastatic cells disseminate and colonize a secondary site, stepwise …
against cancer. As metastatic cells disseminate and colonize a secondary site, stepwise …
PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1
A Poli, FA Pennacchio, A Ghisleni… - Nature …, 2023 - nature.com
Abstract Phosphatidylinositol-5-phosphate (PtdIns5P)− 4-kinases (PIP4Ks) are stress-
regulated phosphoinositide kinases able to phosphorylate PtdIns5P to PtdIns (4, 5) P2. In …
regulated phosphoinositide kinases able to phosphorylate PtdIns5P to PtdIns (4, 5) P2. In …
Spatial confinement toward creating artificial living systems
Lifeforms are regulated by many physicochemical factors, and these factors could be
controlled to play a role in the construction of artificial living systems. Among these factors …
controlled to play a role in the construction of artificial living systems. Among these factors …
[HTML][HTML] Confined migration induces heterochromatin formation and alters chromatin accessibility
During migration, cells often squeeze through small constrictions, requiring extensive
deformation. We hypothesized that nuclear deformation associated with such confined …
deformation. We hypothesized that nuclear deformation associated with such confined …
Nuclear envelope wrinkling predicts mesenchymal progenitor cell mechano-response in 2D and 3D microenvironments
Exogenous mechanical cues are transmitted from the extracellular matrix to the nuclear
envelope (NE), where mechanical stress on the NE mediates shuttling of transcription …
envelope (NE), where mechanical stress on the NE mediates shuttling of transcription …
A flagellate-to-amoeboid switch in the closest living relatives of animals
Amoeboid cell types are fundamental to animal biology and broadly distributed across
animal diversity, but their evolutionary origin is unclear. The closest living relatives of …
animal diversity, but their evolutionary origin is unclear. The closest living relatives of …
Microengineering 3D Collagen Matrices with Tumor‐Mimetic Gradients in Fiber Alignment
Collagen fibers in the 3D tumor microenvironment (TME) exhibit complex alignment
landscapes that are critical in directing cell migration through a process called contact …
landscapes that are critical in directing cell migration through a process called contact …