Multicomponent reactions for the synthesis of bioactive compounds: A review

CS Graebin, FV Ribeiro, KR Rogério… - Current Organic …, 2019 - ingentaconnect.com
Multicomponent reactions (MCRs) are composed of three or more reagents in which the final
product has all or most of the carbon atoms from its starting materials. These reactions …

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Z Zhao, X Dai, C Li, X Wang, J Tian, Y Feng… - European journal of …, 2020 - Elsevier
The pyrazolone structural motif is a critical element of drugs aimed at different biological end-
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …

A critical review on recent trends on pharmacological applications of pyrazolone endowed derivatives

G Mustafa, M Zia-ur-Rehman, SH Sumrra… - Journal of Molecular …, 2022 - Elsevier
Pyrazolone is a well-known influential synthon for the synthesis of many molecules which
hold remarkable potential in the advancement of functional materials, coordination …

Synthesis, reactions and application of chalcones: A systematic review

MA Shalaby, SA Rizk, AM Fahim - Organic & Biomolecular Chemistry, 2023 - pubs.rsc.org
Chalcones are a group of naturally occurring compounds that have biological effects that
include anti-inflammatory, anti-cancer, and antibacterial properties. Current chalcone …

Synthesis, reactions, and applications of pyrimidine derivatives

M Tolba, A El-Dean, M Ahmed… - Current Chemistry …, 2022 - m.growingscience.com
Pyrimidine compounds continue to attract great interest in the field of organic synthesis due
to their various chemical and biological applications observed, especially in recent times. As …

Synthesis and antioxidant activity of 1, 3, 4-oxadiazole tagged thieno [2, 3-d] pyrimidine derivatives

Y Kotaiah, N Harikrishna, K Nagaraju… - European Journal of …, 2012 - Elsevier
This study represents the synthesis of a new series of N-substituted phenyl-5-methyl-6-(5-(4-
substituted phenyl)-1, 3, 4-oxadiazol-2-yl) thieno [2, 3-d] pyrimidin-4-amine derivatives (4a …

2-Aminothiophene scaffolds: Diverse biological and pharmacological attributes in medicinal chemistry

K Bozorov, LF Nie, J Zhao, HA Aisa - European journal of medicinal …, 2017 - Elsevier
Aminothiophenes are important five-membered heterocyclic building blocks in organic
synthesis, and the chemistry of these small molecules is still developing based on the …

New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies

DH Dawood, MM Sayed, STK Tohamy, ES Nossier - ACS omega, 2023 - ACS Publications
The antibiotic resistance problems constitute a considerable threat to human health
worldwide; thus, the discovery of new antimicrobial candidates to conquer this issue is an …

Novel 2‐cyanoacrylamido‐4,5,6,7‐tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents

FM Sroor, MM Aboelenin, KF Mahrous… - Archiv der …, 2020 - Wiley Online Library
Abstract Ethyl 2‐acrylamido‐4, 5, 6, 7‐tetrahydrobenzo [b] thiophene‐3‐carboxylate as well
as its corresponding bis‐derivatives, 5–10, with aliphatic linkers were synthesized, fully …

Synthesis, single crystal, characterization and computational study of 2-amino-N-cyclopropyl-5-ethyl-thiophene-3-carboxamide

G Khanum, A Fatima, N Siddiqui, DD Agarwal… - Journal of Molecular …, 2022 - Elsevier
amino-N-cyclopropyl-5-ethylthiophene-3-carboxamide (ACPETC)(C 10 H 14 N 2 OS) has
been synthesized, characterized via single-crystal X-ray diffraction at 296 K and studied …