Multicomponent reactions for the synthesis of bioactive compounds: A review
CS Graebin, FV Ribeiro, KR Rogério… - Current Organic …, 2019 - ingentaconnect.com
Multicomponent reactions (MCRs) are composed of three or more reagents in which the final
product has all or most of the carbon atoms from its starting materials. These reactions …
product has all or most of the carbon atoms from its starting materials. These reactions …
Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect
Z Zhao, X Dai, C Li, X Wang, J Tian, Y Feng… - European journal of …, 2020 - Elsevier
The pyrazolone structural motif is a critical element of drugs aimed at different biological end-
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …
A critical review on recent trends on pharmacological applications of pyrazolone endowed derivatives
Pyrazolone is a well-known influential synthon for the synthesis of many molecules which
hold remarkable potential in the advancement of functional materials, coordination …
hold remarkable potential in the advancement of functional materials, coordination …
Synthesis, reactions and application of chalcones: A systematic review
Chalcones are a group of naturally occurring compounds that have biological effects that
include anti-inflammatory, anti-cancer, and antibacterial properties. Current chalcone …
include anti-inflammatory, anti-cancer, and antibacterial properties. Current chalcone …
Synthesis, reactions, and applications of pyrimidine derivatives
Pyrimidine compounds continue to attract great interest in the field of organic synthesis due
to their various chemical and biological applications observed, especially in recent times. As …
to their various chemical and biological applications observed, especially in recent times. As …
Synthesis and antioxidant activity of 1, 3, 4-oxadiazole tagged thieno [2, 3-d] pyrimidine derivatives
Y Kotaiah, N Harikrishna, K Nagaraju… - European Journal of …, 2012 - Elsevier
This study represents the synthesis of a new series of N-substituted phenyl-5-methyl-6-(5-(4-
substituted phenyl)-1, 3, 4-oxadiazol-2-yl) thieno [2, 3-d] pyrimidin-4-amine derivatives (4a …
substituted phenyl)-1, 3, 4-oxadiazol-2-yl) thieno [2, 3-d] pyrimidin-4-amine derivatives (4a …
2-Aminothiophene scaffolds: Diverse biological and pharmacological attributes in medicinal chemistry
K Bozorov, LF Nie, J Zhao, HA Aisa - European journal of medicinal …, 2017 - Elsevier
Aminothiophenes are important five-membered heterocyclic building blocks in organic
synthesis, and the chemistry of these small molecules is still developing based on the …
synthesis, and the chemistry of these small molecules is still developing based on the …
New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies
DH Dawood, MM Sayed, STK Tohamy, ES Nossier - ACS omega, 2023 - ACS Publications
The antibiotic resistance problems constitute a considerable threat to human health
worldwide; thus, the discovery of new antimicrobial candidates to conquer this issue is an …
worldwide; thus, the discovery of new antimicrobial candidates to conquer this issue is an …
Novel 2‐cyanoacrylamido‐4,5,6,7‐tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents
FM Sroor, MM Aboelenin, KF Mahrous… - Archiv der …, 2020 - Wiley Online Library
Abstract Ethyl 2‐acrylamido‐4, 5, 6, 7‐tetrahydrobenzo [b] thiophene‐3‐carboxylate as well
as its corresponding bis‐derivatives, 5–10, with aliphatic linkers were synthesized, fully …
as its corresponding bis‐derivatives, 5–10, with aliphatic linkers were synthesized, fully …
Synthesis, single crystal, characterization and computational study of 2-amino-N-cyclopropyl-5-ethyl-thiophene-3-carboxamide
G Khanum, A Fatima, N Siddiqui, DD Agarwal… - Journal of Molecular …, 2022 - Elsevier
amino-N-cyclopropyl-5-ethylthiophene-3-carboxamide (ACPETC)(C 10 H 14 N 2 OS) has
been synthesized, characterized via single-crystal X-ray diffraction at 296 K and studied …
been synthesized, characterized via single-crystal X-ray diffraction at 296 K and studied …