Visceral leishmaniasis: Epidemiology, diagnosis, and treatment regimens in different geographical areas with a focus on pediatrics

S Scarpini, A Dondi, C Totaro, C Biagi, F Melchionda… - Microorganisms, 2022 - mdpi.com
Visceral Leishmaniasis (VL) is a vector-borne disease caused by an intracellular protozoa of
the genus Leishmania that can be lethal if not treated. VL is caused by Leishmania donovani …

Advancement in leishmaniasis diagnosis and therapeutics: An update

D Kumari, S Perveen, R Sharma, K Singh - European Journal of …, 2021 - Elsevier
Leishmaniasis is regarded as a neglected tropical disease by World Health Organization
(WHO) and is ranked next to malaria as the deadliest protozoan disease. The primary …

Laboratory diagnosis of cutaneous and visceral leishmaniasis: current and future methods

JQ Reimão, EM Coser, MR Lee, AC Coelho - Microorganisms, 2020 - mdpi.com
Leishmaniasis is a neglected tropical disease with two main clinical forms: cutaneous and
visceral leishmaniasis. Diagnosis of leishmaniasis is still a challenge, concerning the …

From infection to vaccination: reviewing the global burden, history of vaccine development, and recurring challenges in global leishmaniasis protection

G Volpedo, RH Huston, EA Holcomb… - Expert review of …, 2021 - Taylor & Francis
Introduction Leishmaniasis is a major public health problem and the second most lethal
parasitic disease in the world due to the lack of effective treatments and vaccines. Even …

Laboratory diagnostics for human Leishmania infections: a polymerase chain reaction-focussed review of detection and identification methods

I Gow, NC Smith, D Stark, J Ellis - Parasites & Vectors, 2022 - Springer
Leishmania infections span a range of clinical syndromes and impact humans from many
geographic foci, but primarily the world's poorest regions. Transmitted by the bite of a female …

G-quadruplex DNAzyme-substrated CRISPR/Cas12 assay for label-free detection of single-celled parasitic infection

H Gao, M Feng, F Li, K Zhang, T Zhang, Z Zhang… - ACS …, 2022 - ACS Publications
Early diagnosis of parasitic diseases can dramatically alleviate medical, economic, and
social burdens. Herein, we report a sensitive and label-free assay for diagnosing single …

Visceral leishmaniasis elimination targets in India, strategies for preventing resurgence

S Sundar, OP Singh, J Chakravarty - Expert review of anti-infective …, 2018 - Taylor & Francis
Introduction: Visceral leishmaniasis (VL) is a fatal parasitic disease caused by a parasite
belonging to the Leishmania donovani complex and transmitted by infected female …

Molecular diagnosis of leishmaniasis: quantification of parasite load by a real-time PCR assay with high sensitivity

G Castelli, F Bruno, S Reale, S Catanzaro, V Valenza… - Pathogens, 2021 - mdpi.com
Real-time PCR was developed to quantify Leishmania infantum kinetoplast DNA and
optimized to achieve a sensitivity of 1 parasite/mL. For this purpose, we cloned the …

Virulence factors of Leishmania parasite: Their paramount importance in unraveling novel vaccine candidates and therapeutic targets

D Kumari, S Mahajan, P Kour, K Singh - Life sciences, 2022 - Elsevier
Leishmaniasis is a neglected tropical disease and remains a global concern for healthcare.
It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and …

Diagnosis of visceral and cutaneous leishmaniasis using loop-mediated isothermal amplification (LAMP) protocols: a systematic review and meta-analysis

AC Erber, PJ Sandler, DM de Avelar, I Swoboda… - Parasites & vectors, 2022 - Springer
Sensitive, reliable and fast diagnostic tools that are applicable in low-resource settings, at
the point of care (PoC), are seen as crucial in the fight against visceral leishmaniasis (VL) …