[HTML][HTML] Bioactive natural compounds against human coronaviruses: a review and perspective

Y Xian, J Zhang, Z Bian, H Zhou, Z Zhang, Z Lin… - … Pharmaceutica Sinica B, 2020 - Elsevier
Coronaviruses (CoVs), a family of enveloped positive-sense RNA viruses, are characterized
by club-like spikes that project from their surface, unusually large RNA genome, and unique …

Matrine: A review of its pharmacology, pharmacokinetics, toxicity, clinical application and preparation researches

X Li, Z Tang, L Wen, C Jiang, Q Feng - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance “Dogel ebs” was known as Sophora flavescens Ait., which
has been widely utilized in the clinical practice of traditional Chinese Mongolian herbal …

Apigenin-oxymatrine binary co-amorphous mixture: Enhanced solubility, bioavailability, and anti-inflammatory effect

B Li, Y Hu, T Wu, Y Feng, C Jiang, H Du, S Lu - Food Chemistry, 2022 - Elsevier
Apigenin (APG) is a functional ingredient in many foods, but its poor water solubility results
in low bioavailability. This study aimed at delivering APG and improving bioavailability by a …

[HTML][HTML] Alkaloids as potential antivirals. A comprehensive review

S Faisal, SL Badshah, B Kubra, AH Emwas… - Natural Products and …, 2023 - Springer
Alkaloids are a diverse group of natural phytochemicals. These phytochemicals in plants
provide them protection against pests, and herbivorous organisms and also control their …

[HTML][HTML] Strawberry and ginger silver nanoparticles as potential inhibitors for SARS-CoV-2 assisted by in silico modeling and metabolic profiling

MM Al-Sanea, N Abelyan, MA Abdelgawad, A Musa… - Antibiotics, 2021 - mdpi.com
SARS-CoV-2 (COVID-19), a novel coronavirus causing life-threatening pneumonia, caused
a pandemic starting in 2019 and caused unprecedented economic and health crises all over …

Chemical diversity, biological activities and Traditional uses of and important Chinese herb Sophora

P Sun, W Zhao, Q Wang, L Chen, K Sun, Z Zhan… - Phytomedicine, 2022 - Elsevier
Abstract Background Sophora flavescens Aiton (SF), also known as Kushen (Chinese: 苦参),
has been an important species in Chinese medicine since the Qin and Han dynasties. It is …

Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis …

D Luo, X Dai, H Tian, C Fan, H Xie, N Chen, J Wang… - Phytomedicine, 2023 - Elsevier
Background Novel compounds and more efficient treatment options are urgently needed for
the treatment of non-small cell lung cancer (NSCLC). The decoction of Sophora flavescens …

[HTML][HTML] Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

HI Abd-Alla, D Souguir, MO Radwan - Archives of pharmacal research, 2021 - Springer
Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third
largest family of flowering plants. The genus Sophora comprises approximately 52 species …

Progress of plant medicine derived extracts and alkaloids on modulating viral infections and inflammation

H Ti, Z Zhuang, Q Yu, S Wang - Drug design, development and …, 2021 - Taylor & Francis
Viral infectious diseases are serious threats to human health in both developing and
developed countries. Although there is the continued development of new drugs from …

Complexation of apigenin and oxymatrine leading to enhanced anti-inflammatory activity

D Yuan, Z Wang, B Li, X Li, Y Wang… - Journal of Natural …, 2023 - ACS Publications
Apigenin (APG) is a well-known dietary flavonoid with multiple bioactivities, but its poor
aqueous solubility may result in low oral bioavailability and thus compromised therapeutic …