Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

Purpose Hypoxia is a major regulator of angiogenesis and always influences the release of
exosomes in various types of tumors. The present review aimed to assess the role of …

Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …

Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …

Hypoxia, and hypoxia inducible factor-1 (HIF-1), can induce tumor resistance to radiation
therapy. To overcome hypoxia-induced radiation resistance, recent studies have described …

Highly sensitive and specific non-invasive molecular imaging methods are particularly
desirable for the early detection of cancers. Here we report a near-infrared optical imaging …

The idea of tumor dormancy originated from clinical findings that recurrence of cancer
occurs several years or even several decades after surgical resection of the primary tumor …

Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer
cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence …

Simple Summary Some regions of aggressive malignancies experience hypoxia due to
inadequate blood supply. Cancer cells adapting to hypoxic conditions somehow become …