Cellular differentiation is associated with dynamic chromatin remodeling in establishing a
cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and …

The mouse is a genetically tractable model organism widely used to study mammalian
development and disease. However, mouse metaphase II (mII) oocytes are exquisitely …

Although pluripotent stem cells were recently discovered in postnatal testis, attempts to
analyze their developmental potential have led to conflicting claims that spermatogonial …

Spermatogonial stem cells (SSCs) have unique characteristics in that they produce sperm
that transmit genetic information from generation to generation and they can be …

To assess adult stem cell differentiation in the testis, we injected bone marrow cells from
adult green fluorescent protein (GFP) transgenic mice into the seminiferous tubules and the …

Spermatogenesis is maintained by a pool of spermatogonial stem cells (SSCs). Analyses of
the molecular profile of SSCs have revealed the existence of subsets, indicating that the …

Infertility has become a major health issue in the world. It affects the social life of couples
and of all infertility cases; approximately 40–50% is due to “male factor” infertility. Male …

While bone marrow-derived mesenchymal stem cells are known and have been
investigated for a long time, mesenchymal stem cells derived from the adipose tissue were …

Random integration of conventional gene delivery vectors such as viruses, plasmids, P1
phage-derived artificial chromosomes, bacterial artificial chromosomes and yeast artificial …

In pluripotent stem cells, the interplay between signaling cues, epigenetic regulators and
transcription factors orchestrates developmental potency. Flexibility in gene expression …