Spermatogonial stem cells are required for the initiation of spermatogenesis and the
continuous production of sperm. In addition, they can acquire pluripotency and differentiate …

The loss of germ cells and spermatogenic failure in non-obstructive azoospermia are
believed to be the main causes of male infertility. Laboratory studies have used in vitro …

Potential applications of stem cells in medicine range from their inclusion in disease
modeling and drug discovery to cell transplantation and regenerative therapies. However …

Poised (bivalent) chromatin is defined by the simultaneous presence of histone
modifications associated with both gene activation and repression. This epigenetic feature …

Pluripotency is defined as the potential of a cell to differentiate into cells of the three germ
layers: endoderm, mesoderm and ectoderm. In vivo, the presence of pluripotent stem cells is …

This manuscript comprehensively reviews the interrelationship between spermatogonial
stem cells (SSCs) and the JAK/STAT signaling pathway. Spermatogonial stem cells in the …

Stem cells have fascinated scientists for a long time and huge research efforts have been
put into them as they have the potential to regenerate diseased organs. Besides embryonic …

Men's reproductive health exclusively depends on the appropriate maturation of certain
germ cells known as sperm. Certain illnesses, such as Klinefelter syndrome, cryptorchidism …

Stem cells represent a unique population of cells with self-renewal capacity. Although they
are important therapeutic targets, the genetic manipulation of tissue-specific stem cells has …

The founder cells of the gametes are primordial germ cells (PGCs). In mammals, PGCs are
specified early during embryonic development, at the boundary between embryonic and …