Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent
kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and …

Abstract Cyclin D1 (CCND1), a crucial mediator of cell cycle progression, possesses many
mutation types with different mutation frequencies in human cancers. The G870A mutation is …

Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common
alterations in prostate cancer (PCa); however, the tumor-suppressive functions of CHD1 and …

Despite aggressive treatment for localized cancer, prostate cancer (PC) remains a leading
cause of cancer-related death for American men due to a subset of patients progressing to …

ABSTRACT AR (androgen receptor) signaling is crucial for the development and
maintenance of the prostate as well as the initiation and progression of prostate cancer …

Pre-mRNA splicing is a fundamental process that plays a considerable role in generating
protein diversity. Pre-mRNA splicing is also the key to the pathology of numerous diseases …

Prostate cancer is one of the most commonly diagnosed cancers in men, and androgen
deprivation therapy still represents the primary treatment for prostate cancer patients. This …

RB loss occurs commonly in neoplasia but its contributions to advanced cancer have not
been assessed directly. Here we show that RB loss in multiple murine models of cancer …

Background The presence of multiple molecular aberrations in patients with breast cancer
may correlate with worse outcomes. Case Presentations We performed in-depth molecular …