Metabolomics comprises the methods and techniques that are used to measure the small
molecule composition of biofluids and tissues, and is actually one of the most rapidly …

As the global population becomes older, understanding the impact of aging on health and
disease becomes paramount. Recent advancements in multiomic technology have allowed …

In association with sleep–wake and fasting–feeding cycles, organisms experience dramatic
oscillations in energetic demands and nutrient supply. It is therefore not surprising that …

Metabolomics and artificial intelligence (AI) form a synergistic partnership. Metabolomics
generates large datasets comprising hundreds to thousands of metabolites with complex …

Background: While establishing efficacy in translational models and humans through
clinically-relevant endpoints for disease is of great interest, assessing the potential toxicity of …

Drug repositioning has shorter developmental time, lower cost and less safety risk than
traditional drug development process. The current study aims to repurpose marketed drugs …

Here we developed a novel strategy of isotope labeling in combination with high-
performance liquid chromatography–double precursor ion scan mass spectrometry (IL–LC …

Acute kidney injury (AKI) is a severe and frequent condition in hospitalized patients.
Currently, no efficient therapy of AKI is available. Therefore, efforts focus on early prevention …

Studying the effects of drugs on the metabolome constitutes a huge part of the metabolomics
discipline. Whether the approach is associated with drug discovery (altered pathways due to …

In this work, an in vitro liver model in a microfluidic device to imitate and detect prodrug
metabolism was developed. A widely used prodrug capecitabine (CAP), which needs to be …