Mitochondrial diseases are a group of genetic disorders that are characterized by defects in
oxidative phosphorylation and caused by mutations in genes in the nuclear DNA (nDNA) …

Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (DOA) are
the two most common inherited optic neuropathies in the general population. Both disorders …

For nearly three decades, the sequence of the human mitochondrial genome (mtDNA) has
provided a molecular framework for understanding maternally inherited diseases. However …

Background: Leber hereditary optic neuropathy (LHON) leads to bilateral central vision loss.
In a clinical trial setting, idebenone has been shown to be safe and to provide a trend toward …

Purpose Leber hereditary optic neuropathy (LHON) is a disorder characterized by severe
and rapidly progressive visual loss when caused by a mutation in the mitochondrial gene …

Additional neurological features have recently been described in seven families transmitting
pathogenic mutations in OPA1, the most common cause of autosomal dominant optic …

Leber hereditary optic neuropathy (LHON) is one of the most common inherited optic
neuropathies causing bilateral central vision loss. The disorder results from point mutations …

Pluripotent stem cells hold significant promise in regenerative medicine due to their
unlimited capacity for self-renewal and potential to differentiate into any cell type of the body …

Dominant optic atrophy (DOA), and axonal peripheral neuropathy (Charcot-Marie-Tooth type
2, or CMT2) are hereditary neurodegenerative disorders most commonly caused by …