Lung cancer is the leading cause of cancer death in men and women. Lung
adenocarcinoma (LUAD), represents approximately 40% of all lung cancer cases. Advances …

Introduction: The thiazolidinedione (TZD) class of PPAR-γ ligands is predominantly known
for its insulin sensitization activity. Unfortunately, these drugs have discernible side effects at …

Thioredoxin reductase (TrxR) is overpressed in many human tumors and has a key role in
regulating intracellular redox balance. Recently, thioredoxin system has emerged as a …

Non-small-cell lung cancer (NSCLC) is the most prevalent malignancy worldwide given its
high incidence, considerable mortality, and poor prognosis. The anti-malaria compounds …

Inflammatory stimuli clearly contribute to lung cancer development and progression, but the
underlying pathogenic mechanisms are not fully understood. We found that the …

Non-small cell lung cancer (NSCLC) is the dominant type of lung cancer. Molecular
targeting has highly improved the treatment efficacy of lung cancer, but new challenges …

Abstract Aims Mutant EGFR Non-small cell lung cancer has benefit from gefitinib, but it has
limited effect for wild-type EGFR tumors. Shikonin, a natural naphthoquinone isolated from a …

Abstract Homeobox B5 (HOXB5), a member of the HOX gene family, has been shown to
play an important role in tumor progression. However, the expression and functional role of …

A series of glycosyl triazol linked 18β-glycyrrhetinic acid (GA) derivatives have been
synthesized using 1, 3-dipolar cycloaddition reaction of per-O-acetylated glycosyl azide …

Many drugs in common use possess pleiotropic properties that make them capable of
interfering with carcinogenesis mechanisms. We discuss here the ability of pharmacological …