[HTML][HTML] Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer

H Zhang, C Qin, C An, X Zheng, S Wen, W Chen, X Liu… - Molecular cancer, 2021 - Springer
Abstract The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and
Jennifer Doudna for the development of the Clustered regularly interspaced short …

[HTML][HTML] Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer

X Yang, T Ye, H Liu, P Lv, C Duan, X Wu, K Jiang, H Lu… - Molecular cancer, 2021 - Springer
Circular RNAs (circRNAs), which are single-stranded closed-loop RNA molecules lacking
terminal 5′ caps and 3′ poly (A) tails, are attracting increasing scientific attention for their …

[HTML][HTML] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

MA Feitelson, A Arzumanyan, RJ Kulathinal… - Seminars in cancer …, 2015 - Elsevier
Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

LW Shen, HJ Mao, YL Wu, Y Tanaka, W Zhang - Biochimie, 2017 - Elsevier
Influenza virus and coronavirus epidemics or pandemics have occurred in succession
worldwide throughout the early 21st century. These epidemics or pandemics pose a major …

[HTML][HTML] Androgen receptor structure, function and biology: from bench to bedside

RA Davey, M Grossmann - The clinical biochemist reviews, 2016 - ncbi.nlm.nih.gov
The actions of androgens such as testosterone and dihydrotestosterone are mediated via
the androgen receptor (AR), a ligand-dependent nuclear transcription factor and member of …

Urinary bladder cancer in dogs, a naturally occurring model for cancer biology and drug development

DW Knapp, JA Ramos-Vara, GE Moore… - ILAR …, 2014 - academic.oup.com
Each year more than 65,000 people are diagnosed with urinary bladder cancer, and more
than 14,000 people die from the disease in the United States. Studies in relevant animal …

[HTML][HTML] Bioactive compounds: natural defense against cancer?

S Subramaniam, KR Selvaduray, AK Radhakrishnan - Biomolecules, 2019 - mdpi.com
Cancer is a devastating disease that has claimed many lives. Natural bioactive agents from
plants are gaining wide attention for their anticancer activities. Several studies have found …

International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023

TP Burris, IMS de Vera, I Cote, CA Flaveny… - Pharmacological …, 2023 - ASPET
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

[HTML][HTML] Long noncoding RNA DANCR promotes invasion of prostate cancer through epigenetically silencing expression of TIMP2/3

J Jia, F Li, XS Tang, S Xu, Y Gao, Q Shi, W Guo… - Oncotarget, 2016 - ncbi.nlm.nih.gov
LncRNA DANCR suppresses differentiation of epithelial cells, however, its function in
prostate cancer development is still unknown. In the present study, we found the expression …

An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR-204 promotes the invasion and metastasis of triple-negative breast cancer

F Yang, Y Shen, W Zhang, J Jin, D Huang… - Cell Death & …, 2018 - nature.com
Androgen receptor (AR) is emerging as a novel prognostic biomarker in triple-negative
breast cancer (TNBC), but the underlying mechanisms remain unknown. As accumulating …