The IL-17 family of cytokines in health and disease
The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …
IL-17 receptor–based signaling and implications for disease
IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes,
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …
The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries
Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T
(Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations …
(Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations …
Myelination-independent functions of oligodendrocyte precursor cells in health and disease
Oligodendrocyte precursor cells (OPCs) are a population of tissue-resident glial cells found
throughout the CNS, constituting approximately 5% of all CNS cells and persisting from …
throughout the CNS, constituting approximately 5% of all CNS cells and persisting from …
Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system,
and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory …
and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory …
Oligodendrocytes in development, myelin generation and beyond
S Kuhn, L Gritti, D Crooks, Y Dombrowski - Cells, 2019 - mdpi.com
Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …
How neuroinflammation contributes to neurodegeneration
RM Ransohoff - Science, 2016 - science.org
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …
Astrocytes: key regulators of neuroinflammation
E Colombo, C Farina - Trends in immunology, 2016 - cell.com
Astrocytes are crucial regulators of innate and adaptive immune responses in the injured
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …
An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression
Q Luo, Y Liu, K Shi, X Shen, Y Yang, X Liang, L Lu… - Immunity, 2023 - cell.com
Summary Anti-interleukin-17 (IL-17) therapy has been used in various autoimmune
diseases. However, the efficacy is unexpectedly limited in several IL-17-associated …
diseases. However, the efficacy is unexpectedly limited in several IL-17-associated …
The role of astrocytes in multiple sclerosis
The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS)
lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes …
lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes …