[HTML][HTML] Deep learning in cancer diagnosis, prognosis and treatment selection

KA Tran, O Kondrashova, A Bradley, ED Williams… - Genome Medicine, 2021 - Springer
Deep learning is a subdiscipline of artificial intelligence that uses a machine learning
technique called artificial neural networks to extract patterns and make predictions from …

Artificial intelligence aids in development of nanomedicines for cancer management

P Tan, X Chen, H Zhang, Q Wei, K Luo - Seminars in cancer biology, 2023 - Elsevier
Over the last decade, the nanomedicine has experienced unprecedented development in
diagnosis and management of diseases. A number of nanomedicines have been approved …

On the opportunities and risks of foundation models

R Bommasani, DA Hudson, E Adeli, R Altman… - arXiv preprint arXiv …, 2021 - arxiv.org
AI is undergoing a paradigm shift with the rise of models (eg, BERT, DALL-E, GPT-3) that are
trained on broad data at scale and are adaptable to a wide range of downstream tasks. We …

oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data

D Maeser, RF Gruener, RS Huang - Briefings in bioinformatics, 2021 - academic.oup.com
Cell line drug screening datasets can be utilized for a range of different drug discovery
applications from drug biomarker discovery to building translational models of drug …

SynergyFinder plus: toward better interpretation and annotation of drug combination screening datasets

S Zheng, W Wang, J Aldahdooh… - Genomics …, 2022 - academic.oup.com
Combinatorial therapies have been recently proposed to improve the efficacy of anticancer
treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug …

[PDF][PDF] Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the future

D Akhoundova, MA Rubin - Cancer Cell, 2022 - cell.com
Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

[HTML][HTML] Gene expression based inference of cancer drug sensitivity

S Chawla, A Rockstroh, M Lehman, E Ratther… - Nature …, 2022 - nature.com
Inter and intra-tumoral heterogeneity are major stumbling blocks in the treatment of cancer
and are responsible for imparting differential drug responses in cancer patients. Recently …

Predicting cellular responses to complex perturbations in high‐throughput screens

M Lotfollahi, A Klimovskaia Susmelj… - Molecular systems …, 2023 - embopress.org
Recent advances in multiplexed single‐cell transcriptomics experiments facilitate the high‐
throughput study of drug and genetic perturbations. However, an exhaustive exploration of …

[HTML][HTML] Role of ctDNA in breast cancer

M Sant, A Bernat-Peguera, E Felip, M Margelí - Cancers, 2022 - mdpi.com
Simple Summary Circulating tumor DNA is DNA released by the tumor into the bloodstream.
In breast cancer, it is used mainly in research or in clinical trials, but it will likely be used in …

[HTML][HTML] Machine learning in the prediction of cancer therapy

R Rafique, SMR Islam, JU Kazi - Computational and Structural …, 2021 - Elsevier
Resistance to therapy remains a major cause of cancer treatment failures, resulting in many
cancer-related deaths. Resistance can occur at any time during the treatment, even at the …