Abstract The ESKAPE (Escherichia coli/E. coli, Staphylococcus aureus/S. aureus, Klebsiella
pneumonia/K. pneumoniae, Acinetobacter Baumannii/A. baumannii, Pseudomonas …

Bacterial infection is amongst the most common diseases in community and hospital
settings. Fluoroquinolones, exerting the antibacterial activity through binding to type II …

Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to
DNA substrates and is a clinically-relevant target for the development of new antibacterials …

The development of bacterial resistance to antibiotics and the consequent lack of effective
therapy is one of the biggest problems in modern medicine. A consequence of these …

Quinolones are a type of bicyclic privileged building block with immense therapeutic
potential. They are known for their crucial role in modulating numerous diseases conditions …

This narrative review paper provides an up-to-date overview of the potential of novel
synthetic and semisynthetic compounds as antibacterials that target virulence traits in …

Macrolide antibiotics are macrocyclic compounds that are clinically used and prescribed for
the treatment of upper and lower respiratory tract infections. They inhibit the synthesis of …

Study Background & Objective: After the influenza pandemic (1918), COVID-19 was
declared a Vth pandemic by the WHO in 2020. SARS-CoV-2 is an RNA-enveloped single …

A method for the hydroperfluoroalkylation of alkenes with 1, 2-dibromotetrafluoroethane
leading to tetrafluorinated bromides is described. The reaction is conveniently performed …

N, N‐Dimethylformamide dimethyl acetal (DMF‐DMA) reagent can react with different
functional groups of organic compounds. Enamines and dimethylamino imines are obtained …