Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …

Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Hepatocellular carcinoma (HCC) is a deadly tumour whose causative agents are generally
well known, but whose pathogenesis remains poorly understood. Nevertheless, key genetic …

Cold atmospheric plasma (CAP) is a partially ionized gas that gains attention as a well‐
tolerated cancer treatment that can enhance anti‐tumor immune responses, which are …

Diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease
(ESRD), and the prevalence of DKD has increased worldwide during recent years. DKD is …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Innate and acquired resistance towards the conventional therapeutic regimen imposes a
significant challenge for the successful management of cancer for decades. In patients with …

Epigenetic modifications are heritable yet reversible, essential for normal physiological
functions and biological development. Aberrant epigenetic modifications, including DNA …

Non–clear cell renal cell carcinoma (nccRCC) is a broad term that refers to a diverse group
of tumors, each with its own distinct biologic and therapeutic profile. The management of …

RNA methyltransferases (MTases) are ubiquitous enzymes whose hitherto low profile in
medicinal chemistry, contrasts with the surging interest in RNA methylation, the arguably …