Data-driven disease progression models are an emerging set of computational tools that
reconstruct disease timelines for long-term chronic diseases, providing unique insights into …

Recent therapeutic advances provide heightened motivation for accurate diagnosis of the
underlying biologic causes of dementia. This review focuses on the importance of clinical …

Amyloid-β is thought to facilitate the spread of tau throughout the neocortex in Alzheimer's
disease, though how this occurs is not well understood. This is because of the spatial …

Cognitive dysfunction is an important non-motor symptom in amyotrophic lateral sclerosis
(ALS) that has a negative impact on survival and caregiver burden. It shows a wide spectrum …

The neuropathological hallmarks of Alzheimer's disease (AD), Parkinson's disease (PD),
frontotemporal lobar degeneration (FTLD), and amyotrophic lateral sclerosis (ALS) are …

Alzheimer's disease (AD) is classically characterized by senile plaques and neurofibrillary
tangles (NFTs). However, multiple copathologies can be observed in the AD brain and …

Aims Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with complex
aetiology. Despite evidence of neuromuscular junction (NMJ) denervation and 'dying …

Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) is a neuropathologic entity characterized by transactive response DNA-binding protein …

Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease (MND) that
shares a common clinical, genetic and pathologic spectrum with frontotemporal dementia …

Background TDP-43 proteinopathies represent a spectrum of neurological disorders,
anchored clinically on either end by amyotrophic lateral sclerosis (ALS) and frontotemporal …