Interstitial fluid (ISF) refers to the fluid between the parenchymal cells and along the
perivascular spaces (PVS). ISF plays a crucial role in delivering nutrients and clearing waste …

The neurovascular unit (NVU) is a complex structure that facilitates nutrient delivery and
metabolic waste clearance, forms the blood–brain barrier (BBB), and supports fluid …

Assessing glymphatic function using in-vivo imaging method is of great value for
understanding its contribution to major brain diseases. In the present study, we aim to …

In cerebral small vessel disease (CSVD), both white matter hyperintensities (WMH) of
presumed vascular origin and the normal-appearing white matter (NAWM) contain …

Abstract Background White matter hyperintensities (WMHs) are one of the hallmarks of
cerebral small vessel disease (CSVD), but the pathological mechanisms underlying WMHs …

Cerebral small vessel disease is a major contributor to brain disorders in older adults. It is
associated with a much higher risk of stroke and dementia. Due to a lack of clinical and fluid …

Introduction To evaluate the clinical validity of free water (FW), a diffusion tensor imaging–
based biomarker kit proposed by the MarkVCID consortium, by investigating the association …

White matter hyperintensities (WMH) are a typical feature of cerebral small vessel disease
(CSVD), which contributes to about 50% of dementias worldwide. Microstructural alterations …

Cerebral small vessel disease (cSVD) has been widely studied using conventional magnetic
resonance imaging (MRI) methods, although the association between MRI findings and …

Background: Vascular pathology is an important partner of Alzheimer's disease (AD). Both
total cerebral small vessel disease (CSVD) score and white matter free water (FW) are …