Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …

Background Patients with major depression respond to antidepressant treatment, but 10%–
30% of them do not improve or show a partial response coupled with functional impairment …

Objective Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has
shown rapid antidepressant effects, but small study groups and inadequate control …

Importance Exposure to a disaster is common, and one-third or more of individuals severely
exposed may develop posttraumatic stress disorder or other disorders. A systematic …

Background Ketamine is reported to have rapid antidepressant effects; however, there is
limited understanding of the time-course of ketamine effects beyond a single infusion. A …

Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …

Currently available antidepressants have a substantial time lag to induce therapeutic
response and a relatively low efficacy. The development of drugs that addresses these …

The central nervous system (CNS) has the highest concentration of lipids in the organism
after adipose tissue. Among these lipids, the brain is particularly enriched with …

BACKGROUND: Increasing dissatisfaction with the non-specificity of major depression has
led many to propose more specific depressive subtyping models. The present meta-review …

Invasive vagus nerve stimulation has been demonstrated to be an effective treatment in
major depressive episodes. Recently, a novel non-invasive method of stimulating the vagus …