Significance: Reactive oxygen species (ROS) promote genomic instability, altered signal
transduction, and an environment that can sustain tumor formation and growth. The NOX …

The members of the NOX/DUOX family of NADPH oxidases mediate such physiologic
functions as host defense, cell signaling, and thyroid hormone biosynthesis through the …

DNA double-strand breaks (DSBs) are considered as one of the primary causes of cancer
but their induction by hydrogen peroxide (H2O2) is still controversial. In this work, we studied …

Dual oxidases were initially identified as NADPH oxidases producing H 2 O 2 necessary for
thyroid hormone biosynthesis. The crucial role of Duox2 has been demonstrated in patients …

This prospective study investigates the relationship between Hashimoto's thyroiditis (HT)
and thyroid cancer (TC) in patients with thyroid nodules (TNs). We prospectively examined …

Significance: Among the NADPH oxidases, the dual oxidases, DUOX1 and DUOX2,
constitute a distinct subfamily initially called thyroid oxidases, based on their high level of …

Amyotrophic Lateral Sclerosis (ALS) is a progressive motor neurodegenerative disease. Cell
damage in ALS is the result of many different, largely unknown, pathogenetic mechanisms …

Bisphenol A (BPA) is the most common monomer in polycarbonate plastics and an
endocrine disruptor. Though some effects of BPA on thyroid hormone (TH) synthesis and …

Context: Congenital hypothyroidism (CH) associated with goiter or a gland of normal size
has been linked to dual oxidase 2 (DUOX2) mutations in the presence of iodide …

Abstract Dual oxidases (DUOX) 1 and 2 are components of the thyroid H2O2‐generating
system. H2O2 is used by thyroperoxidase to oxidize iodide for thyroid hormonogenesis …