The small intestine displays marked anatomical and functional plasticity that includes
adaptive alterations in adult gut morphology, enteroendocrine cell profile and their hormone …

Cancer remains the second leading cause of mortality, with nearly 10 million deaths
worldwide in 2020. In many cases, radiotherapy is used for its anticancer effects. However …

Scope: The proliferation and differentiation of intestinal stem cells (ISCs) are the basis of
intestinal renewal and regeneration, and gut microbiota plays an important role in it. Dietary …

Obesity is a strong risk factor for cancer progression, posing obesity-related cancer as one of
the leading causes of death. Nevertheless, the molecular mechanisms that endow cancer …

Intestinal surface changes in size and function, but what propels these alterations and what
are their metabolic consequences is unknown. Here we report that the food amount is a …

Obesity promotes a chronic inflammatory and hypercoagulable state that drives
cardiovascular disease, type 2 diabetes, fatty liver disease, and several cancers. Elevated …

A high‑fat diet (HFD) or obesity‑promoting diet is closely associated with metabolic diseases
and intestinal tumors, particularly in middle‑aged individuals (typically 45‑64 years old). The …

Although the jejunum is the main intestinal compartment responsible for lipid digestion and
absorption, most of the studies assessing the impact of dietary lipids on the intestinal …

The effect of inflammation on appetite and food intake has been rarely studied in humans. In
this study, we examined the association of C-reactive protein (CRP), as an inflammatory …

The gut is the primary interface between an animal and food, but how it adapts to qualitative
dietary variation is poorly defined. We find that the Drosophila midgut plastically resizes …