Abstract The COVID-19-, SARS-and MERS-related coronaviruses share many genomic and
structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and …

Nitric oxide and its production by iNOS is an established mechanism critical to tumor
promotion or suppression. Macrophages have important roles in immunity, development …

Imbalance between the activities of pro-inflammatory M1 and anti-inflammatory M2
macrophages in rheumatoid arthritis (RA) induces synovial inflammation and autoimmunity …

Sepsis is a life-threatening clinical syndrome caused by infection. Its pathogenesis is
complex and entails coagulation dysfunction, inflammation, and immune disorders …

Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying
multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized …

Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in
clinical treatment because of dysfunction of macrophage polarization and the inflammatory …

Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …

Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung
diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass …

The treatment of diabetic wound remains a big clinical challenge. Hydrogel that can provide
physical barrier and humidity displays amazing potentials for managing the diabetic wounds …

Background Spinal cord ischemia-reperfusion injury (SCIRI) often leads to neurological
damage and mortality. In this regard, understanding the pathology of SCIRI and preventing …