Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

The impact of IUGR on pancreatic islet development and β-cell function

BH Boehmer, SW Limesand… - Journal of …, 2017 - joe.bioscientifica.com
Placental insufficiency is a primary cause of intrauterine growth restriction (IUGR). IUGR
increases the risk of developing type 2 diabetes mellitus (T2DM) throughout life, which …

New approaches to management of neonatal hypoglycemia

PJ Rozance, WW Hay - Maternal health, neonatology and perinatology, 2016 - Springer
Despite being a very common problem after birth, consensus on how to manage low
glucose concentrations in the first 48 h of life has been difficult to establish and remains a …

Early-life programming of type 2 diabetes mellitus: understanding the association between epigenetics/genetics and environmental factors

FZ Kadayifci, S Haggard, S Jeon, K Ranard… - Current …, 2019 - ingentaconnect.com
Type 2 Diabetes Mellitus is an increasing public health problem that poses a severe social
and economic burden affecting both developed and developing countries. Defects in insulin …

Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep

BH Boehmer, PR Baker, LD Brown… - Journal of …, 2020 - joe.bioscientifica.com
A 9-day infusion of leucine into fetal sheep potentiates fetal glucose-stimulated insulin
secretion (GSIS). However, there were accompanying pancreatic structural changes that …

Challenges in nourishing the intrauterine growth‐restricted foetus–Lessons learned from studies in the intrauterine growth‐restricted foetal sheep

WW Hay Jr, LD Brown, PJ Rozance… - Acta …, 2016 - Wiley Online Library
Previous attempts to improve growth and development of the intrauterine growth‐restricted
(IUGR) foetus during pregnancy have not worked or caused harm. Our research identifies …

[HTML][HTML] A chronic fetal leucine infusion potentiates fetal insulin secretion and increases pancreatic islet size, vascularity, and β cells in late-gestation sheep

BH Boehmer, LD Brown, SR Wesolowski… - The Journal of …, 2020 - Elsevier
Background: Infusion of a complete amino acid mixture into normal late-gestation fetal
sheep potentiates glucose-stimulated insulin secretion (GSIS). Leucine acutely stimulates …

Association between the fetal cerebroplacental ratio and biomarkers of hypoxia and angiogenesis in the maternal circulation at term

KM Irvine, LN Bligh, S Kumar - … Journal of Obstetrics & Gynecology and …, 2020 - Elsevier
Objectives A low fetal cerebroplacental ratio (CPR) in late pregnancy is a marker of a fetus
that has failed to reach its growth potential and is associated with a variety of perinatal and …

A 1 week IGF‐1 infusion decreases arterial insulin concentrations but increases pancreatic insulin content and islet vascularity in fetal sheep

A White, S Louey, EI Chang, BH Boehmer… - Physiological …, 2018 - Wiley Online Library
Fetal insulin is critical for regulation of growth. Insulin concentrations are partly determined
by the amount of β‐cells present and their insulin content. Insulin‐like growth factor‐1 (IGF …

胎儿生长受限的病因研究进展.

焦立媛, 王华, 武硕 - Journal of International Obstetrics & …, 2018 - search.ebscohost.com
胎儿生长受限(FGR) 又称宫内生长受限(IUGR), 是指胎儿在母体, 胎儿自身以及环境因素影响下
未达到其生长潜能, 是产科常见疾病之一, 也是我国围生儿死亡的主要原因之一. FGR …