Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14. 99.1) catalyzes the first two
steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 and COX-2 …

Gallbladder cancer is a relatively rare form of malignancy about which our knowledge is
scant. However, a unique combination of predisposing factors—including genetic …

The sulfonamides constitute an important class of drugs, with several types of
pharmacological agents possessing antibacterial, anti-carbonic anhydrase, diuretic …

Sphenocentrum jollyanum crude extracts and an isolated constituent were evaluated for anti-
inflammatory activity using the carrageenan-induced hind paw oedema of healthy adult …

Celecoxib is an NSAID that was developed as a selective inhibitor of COX-2 and approved
by the FDA for the treatment of various forms of arthritis and the management of acute or …

Searching for a link between inflammation and colon cancer, we have found that the
inflammatory mediator leukotriene D4 (LTD4), via its receptor CysLT1, induces …

Membrane-associated prostaglandin (PG) E 2 synthase-1 (mPGES-1) catalyzes the
conversion of PGH 2 to PGE 2, which contributes to many biological processes. Peroxisome …

Abstract Cyclooxygenase 2 (COX-2) inhibitors are promising antiangiogenic agents in
several preclinical models. The aim of the present study was to evaluate the effect of …

mPGES-1 as a novel target for arthritis : Current Opinion in Rheumatology mPGES-1 as a novel
target for arthritis : Current Opinion in Rheumatology Log in or Register Subscribe to …

✓ Celecoxib (Celebrex) appears to be unique among the class of selective COX-2 inhibitors
(coxibs), because this particular compound exerts a second function that is independent of …