A new series of triazolothiadiazines as potential anticancer agents for targeted therapy of non-small cell lung and colorectal cancers: design, synthesis, in silico and in …
Background: Targeted therapies acting on specific molecular targets in cancer cells with
better curative efficacy and lower toxicity have come into prominence for the management of …
better curative efficacy and lower toxicity have come into prominence for the management of …
Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA)
Aim Inflammation provides favourable microenvironment for cancer development. An
enhanced COX-2 gene expression is a key inflammatory mediator of cancers and the drug …
enhanced COX-2 gene expression is a key inflammatory mediator of cancers and the drug …
Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A …
MH Aziz, DL Wheeler, B Bhamb, AK Verma - Cancer research, 2006 - AACR
Protein kinase C δ (PKCδ), a Ca2+-independent, phospholipid-dependent serine/threonine
kinase, is among the novel PKCs (δ, ε, and η) expressed in mouse epidermis. We reported …
kinase, is among the novel PKCs (δ, ε, and η) expressed in mouse epidermis. We reported …
A new series of thiosemicarbazone‐based anti‐inflammatory agents exerting their action through cyclooxygenase inhibition
In an endeavor to identify potent anti‐inflammatory agents, new thiosemicarbazones (TSCs)
incorporated into a diaryl ether framework (2a–2l) were prepared and screened for their in …
incorporated into a diaryl ether framework (2a–2l) were prepared and screened for their in …
Indomethacin-induced activation of the death receptor-mediated apoptosis pathway circumvents acquired doxorubicin resistance in SCLC cells
DJA De Groot, T Timmer, DCJ Spierings, TKP Le… - British journal of …, 2005 - nature.com
Small-cell lung cancers (SCLCs) initially respond to chemotherapy but are often resistant at
recurrence. A potentially new method to overcome resistance is to combine classical …
recurrence. A potentially new method to overcome resistance is to combine classical …
A review on xanthone derivatives with antiinflammatory effects and their structure–activity relationship
Inflammation is a response to the immune system to protect our body from the infection of
foreign organisms, such as bacteria and viruses. However, uncontrolled acute inflammation …
foreign organisms, such as bacteria and viruses. However, uncontrolled acute inflammation …
[HTML][HTML] Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing
B Ahmetaj-Shala, A Tesfai, C Constantinou… - Biochemical and …, 2017 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, are amongst the most
commonly used medications and produce their anti-inflammatory and analgesic benefits by …
commonly used medications and produce their anti-inflammatory and analgesic benefits by …
Effect of prostaglandins on the regulation of tumor growth
S Ishihara, MAK Rumi, T Okuyama… - … Chemistry-Anti-Cancer …, 2004 - ingentaconnect.com
Prostaglandins (PGs) are involved in mediating or regulating many physiological as well as
pathological processes. Important roles of PGs in the pathophysiology of carcinogenesis …
pathological processes. Important roles of PGs in the pathophysiology of carcinogenesis …
Seyferth–Gilbert Homologation as a Route to 18F‐Labeled Building Blocks: Preparation of Radiofluorinated Phenylacetylenes and Their Application in PET …
P Krapf, R Richarz, EA Urusova, B Neumaier… - 2016 - Wiley Online Library
A convenient method for the preparation of hitherto unknown ([18F] fluorophenyl) acetylenes
([18F] FPAs) using the Seyferth–Gilbert homologation is reported. The novel building blocks …
([18F] FPAs) using the Seyferth–Gilbert homologation is reported. The novel building blocks …
Expression of cyclooxygenase-2 in squamous cell carcinoma and keratoacanthoma and its clinical significance
HK Hua, C Jin, LJ Yang, SQ Tao, XH Zhu - Cell biochemistry and …, 2015 - Springer
Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, catalyzes the
conversion of arachidonic acid to prostanoids. There are two different isoforms of COX …
conversion of arachidonic acid to prostanoids. There are two different isoforms of COX …