KATP channels as molecular sensors of cellular metabolism
CG Nichols - Nature, 2006 - nature.com
In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel
activity provides a unique link between cellular energetics and electrical excitability. Over …
activity provides a unique link between cellular energetics and electrical excitability. Over …
Update of variants identified in the pancreatic β‐cell KATP channel genes KCNJ11 and ABCC8 in individuals with congenital hyperinsulinism and diabetes
E De Franco, C Saint‐Martin, K Brusgaard… - Human …, 2020 - Wiley Online Library
The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic
variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP …
variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP …
Genotype and phenotype correlations in 417 children with congenital hyperinsulinism
KE Snider, S Becker, L Boyajian… - The Journal of …, 2013 - academic.oup.com
Context: Hypoglycemia due to congenital hyperinsulinism (HI) is caused by mutations in 9
genes. Objective: Our objective was to correlate genotype with phenotype in 417 children …
genes. Objective: Our objective was to correlate genotype with phenotype in 417 children …
ATP-Sensitive potassium channels and their physiological and pathophysiological roles.
A Tinker, Q Aziz, Y Li, M Specterman - Compr Physiol, 2018 - qmro.qmul.ac.uk
ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …
Update of mutations in the genes encoding the pancreatic beta‐cell KATP channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes …
SE Flanagan, S Clauin, C Bellanné‐Chantelot… - Human …, 2009 - Wiley Online Library
The beta‐cell ATP‐sensitive potassium (KATP) channel is a key component of stimulus‐
secretion coupling in the pancreatic beta‐cell. The channel couples metabolism to …
secretion coupling in the pancreatic beta‐cell. The channel couples metabolism to …
The genetic basis of congenital hyperinsulinism
Congenital hyperinsulinism (CHI) is biochemically characterised by the dysregulated
secretion of insulin from pancreatic β-cells. It is a major cause of persistent …
secretion of insulin from pancreatic β-cells. It is a major cause of persistent …
The genetics of ATP‐binding cassette transporters
M Dean - Methods in enzymology, 2005 - Elsevier
The ATP‐binding cassette (ABC) superfamily consists of membrane proteins that transport a
wide variety of substrates across membranes. Mutations in ABC transporters cause or …
wide variety of substrates across membranes. Mutations in ABC transporters cause or …
Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension
Background: In pulmonary arterial hypertension (PAH), pathological changes in pulmonary
arterioles progressively raise pulmonary artery pressure and increase pulmonary vascular …
arterioles progressively raise pulmonary artery pressure and increase pulmonary vascular …
KATP channel therapeutics at the bedside
A Jahangir, A Terzic - Journal of molecular and cellular cardiology, 2005 - Elsevier
The family of potassium channel openers regroups drugs that share the property of
activating adenosine triphosphate-sensitive potassium (KATP) channels, metabolic sensors …
activating adenosine triphosphate-sensitive potassium (KATP) channels, metabolic sensors …
Mutations in the genes encoding the pancreatic beta‐cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism
The beta‐cell ATP‐sensitive potassium channel is a key component of stimulus‐secretion
coupling in the pancreatic beta‐cell. The channel couples metabolism to membrane …
coupling in the pancreatic beta‐cell. The channel couples metabolism to membrane …