Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?
LM de la Maza, TL Darville, S Pal - Expert review of vaccines, 2021 - Taylor & Francis
Introduction Chlamydia trachomatis is the most common sexually transmitted bacterial
pathogen in the world. Antibiotic treatment does not prevent against reinfection and a …
pathogen in the world. Antibiotic treatment does not prevent against reinfection and a …
Folding and stabilizing membrane proteins in amphipol A8-35
C Le Bon, A Marconnet, S Masscheleyn, JL Popot… - Methods, 2018 - Elsevier
Membrane proteins (MPs) are important pharmacological targets because of their
involvement in many essential cellular processes whose dysfunction can lead to a large …
involvement in many essential cellular processes whose dysfunction can lead to a large …
Improved protection against Chlamydia muridarum using the native major outer membrane protein trapped in Resiquimod-carrying amphipols and effects in protection …
A new vaccine formulated with the Chlamydia muridarum native major outer membrane
protein (nMOMP) and amphipols was assessed in an intranasal (in) challenge mouse …
protein (nMOMP) and amphipols was assessed in an intranasal (in) challenge mouse …
Recombinant SARS-CoV-2 envelope protein traffics to the trans-Golgi network following amphipol-mediated delivery into human cells
The severe acute respiratory syndrome coronavirus 2 envelope protein (S2-E) is a
conserved membrane protein that is important for coronavirus (CoV) assembly and budding …
conserved membrane protein that is important for coronavirus (CoV) assembly and budding …
Surface Modification of Biodegradable Microparticles with the Novel Host-Derived Immunostimulant CPDI-02 Significantly Increases Short-Term and Long-Term …
JE Parriott, JP Stewart, DD Smith, SM Curran… - Pharmaceutics, 2022 - mdpi.com
Generating long-lived mucosal and systemic antibodies through respiratory immunization
with protective antigens encapsulated in nanoscale biodegradable particles could …
with protective antigens encapsulated in nanoscale biodegradable particles could …
Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67
AM Alshammari, DD Smith, J Parriott… - ACS infectious …, 2020 - ACS Publications
EP67 is a second-generation, human C5a-derived decapeptide agonist of C5a receptor 1
(C5aR1/CD88) that selectively activates mononuclear phagocytes over neutrophils to …
(C5aR1/CD88) that selectively activates mononuclear phagocytes over neutrophils to …
Subunit-based vaccines: challenges in developing protein-based vaccines
The basic purpose of a vaccine is to simulate certain structural features of a pathogen or
other target entities. Initially, successful vaccines consisted of live, attenuated, or inactivated …
other target entities. Initially, successful vaccines consisted of live, attenuated, or inactivated …
Full‐length G glycoprotein directly extracted from rabies virus with detergent and then stabilized by amphipols in liquid and freeze‐dried forms
D Clénet, L Clavier, B Strobbe, C Le Bon… - Biotechnology and …, 2021 - Wiley Online Library
Pathogen surface antigens are at the forefront of the viral strategy when invading host
organisms. These antigens, including membrane proteins (MPs), are broadly targeted by the …
organisms. These antigens, including membrane proteins (MPs), are broadly targeted by the …
[HTML][HTML] Delivery of recombinant SARS-CoV-2 envelope protein into human cells
JM Hutchison, R Capone, DD Luu, A Hadziselimovic… - bioRxiv, 2021 - ncbi.nlm.nih.gov
Abstract SARS-CoV-2 envelope protein (S2-E) is a conserved membrane protein that is
essential to coronavirus assembly and budding. Here, we describe the recombinant …
essential to coronavirus assembly and budding. Here, we describe the recombinant …
Advanced techniques for the study of membrane proteins in complex and native lipid environments.
JM Hutchison - 2021 - ir.vanderbilt.edu
The biophysical and biochemical study of membrane proteins is uniquely challenged by the
lipid bilayer environment in which membrane proteins reside. While fantastic methods have …
lipid bilayer environment in which membrane proteins reside. While fantastic methods have …