[HTML][HTML] Single-cell technologies for the study of antibody-secreting cells

M Broketa, P Bruhns - Frontiers in immunology, 2022 - frontiersin.org
Antibody-secreting cells (ASC), plasmablasts and plasma cells, are terminally differentiated
B cells responsible for large-scale production and secretion of antibodies. ASC are derived …

Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow

M Ferreira-Gomes, Y Chen, P Durek… - Nature …, 2024 - nature.com
Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently
releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different …

Diagnosing chronic endometritis: when simplification fails to clarify

M Murtinger, B Wirleitner, D Spitzer… - Human …, 2022 - academic.oup.com
Reproductive immunology has grown in importance in recent years and has even
developed into a discipline of its own within the field of reproductive medicine. Many aspects …

Revising immune cell coordination: Origins and importance of single‐cell variation

LC Van Eyndhoven, J Tel - European Journal of Immunology, 2022 - Wiley Online Library
Moving from the optimalization of single‐cell technologies to the interpretation of the multi‐
complex single‐cell data, the field of immunoengineering is granted with numerous …

Age-Related Changes in the Clustering of Blood Populations in Cynomolgus Monkeys Depend on Sex and Immune Status

DD Karal-Ogly, AN Shumeev, VV Keburiya, MV Mintel… - Life, 2023 - mdpi.com
Non-anthropoid primates cynomolgus monkeys (Macaca fascicularis), also known as crab-
eating macaques, are increasingly used in biomedical and preclinical studies due to their …

Citrulline enteral administration markedly reduces immunosuppressive extrafollicular plasma cell differentiation in a preclinical model of sepsis

J Gauthier, M Grégoire, F Reizine… - European journal of …, 2023 - Wiley Online Library
The sustained immunosuppression associated with severe sepsis favors an increased
susceptibility to secondary infections and remains incompletely understood. Plasmablast …

Aberrant B-cell activation and B-cell subpopulations in rheumatoid arthritis: analysis by clinical activity, autoantibody seropositivity, and treatment

JJ Morales-Núñez, JF Muñoz-Valle… - Clinical and …, 2023 - academic.oup.com
Few studies analyze the role of B-cell subpopulations in rheumatoid arthritis (RA)
pathophysiology. Therefore, this study aimed to analyze the differences in B-cell …

Comparative analysis of peripheral blood immunoinflammatory landscapes in patients with acute cholangitis and its secondary septic shock using single-cell RNA …

H Zhang, N Wang, Y Xu, M Pei, Y Zheng - Biochemical and Biophysical …, 2023 - Elsevier
Background Acute cholangitis (AC) is a key pathogeny of septic shock, which has a high
mortality rate. AC has significant clinical heterogeneity, but no study has analyzed the …

The cellular biology of plasma cells: Unmet challenges and opportunities

A Bonaud, M Khamyath, M Espéli - Immunology Letters, 2023 - Elsevier
Plasma cells and the antibodies they secrete are paramount for protection against infection
but can also be implicated in diseases including autoantibody-mediated disease and …

Memory B Cells and Plasma Cells

MA McGrath, F Weisel, A Radbruch… - Molecular Biology of B …, 2024 - Elsevier
Immunological memory provided by memory B cells, memory T cells and long-lived
(memory) plasma cells yields long-lasting, effective cellular and humoral immune protection …