The purpose of this review is to provide a brief overview of bioreactor‐based culture systems
as alternatives to conventional two‐and three‐dimensional counterparts. The role …

Rotator cuff tear is one of the most common shoulder problems encountered by orthopedic
surgeons. Due to the slow healing process and high retear rate, rotator cuff tear has …

Numerous studies have indicated that microgravity induces various changes in the cellular
functions of neural stem cells (NSCs), and the use of microgravity to culture tissue …

Musculoskeletal diseases are increasing the prevalence of physical disability worldwide.
Within the body, musculoskeletal soft and hard tissues integrate through specific multitissue …

Highlights•Preferentially directing stem cell differentiation.•Positively influencing cell
function.•Favourably promoting cellular longevity.•Constructively enhancing extracellular …

The link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has
been well recognized. However, the cellular and molecular mechanisms of TSPCs …

Tendon is a tissue that transmits force from muscle to bone. Chronic or acute tendon injuries
are very common, and are always accompanied by pain and a limited range of motion in …

Injured adult tendons do not exhibit optimal healing through a regenerative process,
whereas fetal tendons can heal in a regenerative fashion without scar formation. Hence, we …

Mesenchymal Stem Cells (MSCs) and tissue-specific progenitors have been proposed as
useful tools for regenerative medicine approaches in bone, cartilage and tendon-related …

Rigidity of substrates plays an important role in stem cell fate. Studies are commonly carried
out on isotropically stiff substrate or substrates with unidirectional stiffness gradients …