Tendon injuries are common and present a clinical challenge because they often respond
poorly to treatment and require prolonged rehabilitation. Current treatments often do not …

Tendon repair is a clinical challenge because of the limited understanding on tenogenesis.
The synthesis of type I collagen (Collagen I) and other extracellular matrix are essential for …

Tendon, ligament, and skeletal muscle are highly organized tissues that largely rely on a
hierarchical collagenous matrix to withstand high tensile loads experienced in activities of …

Although human tenocytes and dermal fibroblasts have shown promise in tendon
engineering, no tissue engineered medicine has been developed due to the prolonged ex …

Growing number of musculoskeletal defects increases the demand for engineered tendon.
Our aim was to find an efficient strategy to produce tendon-like matrix in vitro. To allow …

Tendon stem/progenitor cells (TSPCs) have been identified as a rare population in tendons.
In vitro propagation is indispensable to obtain sufficient quantities of TSPCs for therapies …

Background The structural and functional properties of tendon decline with age, and these
changes contribute to tendon disorder. Tendon stem/progenitor cells (TSPCs) play a vital …

Tendon ageing is a complicated process caused by multifaceted pathways and ageing plays
a critical role in the occurrence and severity of tendon injury. The role of tendon …

Tendons are dense connective tissues, which are critical for the integrity and function of our
musculoskeletal system. During tendon aging and degeneration, tendon stem/progenitor …

Both extrinsic and intrinsic tissues contribute to tendon repair, but the origin and molecular
functions of extrinsic tissues in tendon repair are not fully understood. Here we show that …