Cell sheet technology: an emerging approach for tendon and ligament tissue engineering

Y Li, T Deng, D Aili, Y Chen, W Zhu, Q Liu - Annals of Biomedical …, 2024 - Springer
Tendon and ligament injuries account for a substantial proportion of disorders in the
musculoskeletal system. While non-operative and operative treatment strategies have …

[HTML][HTML] Understanding cellular and molecular mechanisms of pathogenesis of diabetic tendinopathy

PP Lu, MH Chen, GC Dai, YJ Li, L Shi… - World Journal of Stem …, 2020 - ncbi.nlm.nih.gov
There is accumulating evidence of an increased incidence of tendon disorders in people
with diabetes mellitus. Diabetic tendinopathy is an important cause of chronic pain, restricted …

China's landscape in regenerative medicine

X Tang, H Qin, X Gu, X Fu - Biomaterials, 2017 - Elsevier
Regenerative medicine is a burgeoning interdisciplinary research field that can impact
healthcare by offering new therapeutic strategies to replace or regenerate human cells …

Efficacy of tendon stem cells in fibroblast-derived matrix for tendon tissue engineering

D Jiang, B Xu, M Yang, Z Zhao, Y Zhang, Z Li - Cytotherapy, 2014 - Elsevier
Background aims After injury, tendons often heal with poor tissue quality and inferior
mechanical properties. Tissue engineering using tendon stem cells (TSCs) is a promising …

Growth and stem cell characteristics of tendon-derived cells with different initial seeding densities: an in vitro study in mouse flexor tendon cells

YF Wu, C Chen, JB Tang, WF Mao - Stem Cells and Development, 2020 - liebertpub.com
Tendon stem/progenitor cells (TSPCs) are considered promising seed cells for tendon
regeneration. Previous studies reported that a low seeding density favors TSPC growth …

HMGB1 Modulates High Glucose‐Induced Erroneous Differentiation of Tendon Stem/Progenitor Cells through RAGE/β‐Catenin Pathway

P Lu, G Dai, L Shi, Y Li, M Zhang… - Stem Cells …, 2024 - Wiley Online Library
The association of tendinopathy with diabetes has been well recognized. Tendon
stem/progenitor cells (TSPCs) play critical roles in tendon repair, regeneration, and …

Combining electrospinning and cell sheet technology for the development of a multiscale tissue engineered ligament construct (TELC)

C Vaquette, PT Sudheesh Kumar… - … Research Part B …, 2018 - Wiley Online Library
Ligament tissue rupture is a common sport injury. Although current treatment modalities can
achieve appropriate reconstruction of the damaged ligament, they present significant …

Enhancing osteogenic differentiation of diabetic tendon stem/progenitor cells through hyperoxia: Unveiling ROS/HIF‐1α signalling axis

M Zhang, GC Dai, YW Zhang, PP Lu… - Journal of Cellular …, 2024 - Wiley Online Library
Diabetic calcific tendinopathy is the leading cause of chronic pain, mobility restriction, and
tendon rupture in patients with diabetes. Tendon stem/progenitor cells (TSPCs) have been …

Perivascular-derived stem cells with neural crest characteristics are involved in tendon repair

W Xu, Y Sun, J Zhang, K Xu, L Pan, L He… - Stem Cells and …, 2015 - liebertpub.com
Tendons and ligaments exhibit limited regenerative capacity following injury, with damaged
tissue being replaced by a fibrotic scar. The physiological role of scar tissue is complex and …

[HTML][HTML] Tenomodulin highly expressing MSCs as a better cell source for tendon injury healing

Y Hou, M Ni, S Lin, Y Sun, W Lin, Y Liu, H Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Tendon injuries are common orthopedic problems which may cause severe morbidity. MSCs
(mesenchymal stem cells) have shown promising effect on tissue engineering and have …