Radiation therapy (RT) is emerging as an interventional modality in the cancer-immunity
cycle, augmenting the activation of an adaptive immune response against tumors. RT …

Context Immunotherapy drugs, particularly checkpoint inhibitors, have recently been
approved by the Food and Drug Administration for various malignancies. Preclinical and …

There is a significant body of evidence demonstrating that radiation therapy (XRT) enhances
the effect of immune therapy. However, the precise mechanisms by which XRT potentiates …

Glioblastoma is the most common adult primary brain tumor and carries a dismal prognosis.
Radiation is a standard first-line therapy, typically deployed following maximal safe surgical …

As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and
protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D …

Rectal cancer remains a challenging disease to treat. Therapy for locally advanced rectal
cancer (LARC), the most frequent presentation, has evolved to include a multimodal …

Besides its direct cytotoxic effect on the tumor cells, radiation therapy is also able to elicit an
immune-mediated systemic anti-tumor response, resulting in tumor regression in irradiated …

Renal cell carcinoma (RCC) is an immunogenic tumor, but uses several immune-
suppressive mechanisms to shift the balance from tumor immune response toward tumor …

Background Glioblastoma (GBM) is one of the most lethal tumors with a poor prognosis. Its
inevitable recurrence is frequently explained by the presence of cancer stem cells. We …

Rapid advancements in radiotherapy and molecularly targeted therapies have resulted in
the development of potential paradigm-shifting use of radiotherapy in the treatment of …