Proteases represent the class of enzymes which occupy a pivotal position with respect to
their physiological roles as well as their commercial applications. They perform both …

Nuclear targeting sequences are essential for the transport of proteins into the nucleus. The
seven-amino-acid nuclear targeting sequence of the SV40 large T antigen has been …

Fragile X syndrome is the most frequent form of inherited mental retardation and is
associated with a fragile site at Xq27. 3. We identified human YAC clones that span fragile X …

Point mutagenesis of the nuclear targeting sequence of nucleoplasmin has identified two
interdependent basic domains. These are separated by 10 intervening" spacer" amino acids …

The proto-oncogene designated erb B2 or HER2 encodes a 185-kilodalton transmembrane
tyrosine kinase (p185 erb B2), whose overexpression has been correlated with a poor …

The DNA binding activity of Fos and Jun is regulated in vitro by a post‐translational
mechanism involving reduction‐oxidation. Redox regulation occurs through a conserved …

The 20S proteasome is the catalytic portion of the 26S proteasome. Constitutively expressed
mammalian 20S proteasomes have three active subunits, β1, β2, and β5, which are …

Abasic (AP) sites are common, potentially mutagenic DNA damages that are attacked by AP
endonucleases. The biological roles of these enzymes in metazoans have not been tested …

To search for genes that can collaborate with myc in lymphomagenesis, we exploited
retroviral insertional mutagenesis in Ep-myc transgenic mice. Moloney murine leukemia …

The amino acid sequence requirements for androgen-dependent androgen receptor nuclear
import were determined by immunostaining transiently expressed full-length wild type and …