The human innate host defense molecules, SP-A1 and SP-A2 variants, differentially affect
survival after infection in mice and in lung transplant patients. SP-A interacts with the …

The global scope and scale of the SARS-CoV-2 pandemic led to huge amounts of important
data from clinical observations and experimental analyses being collected, in particular …

The global spread of SARS-CoV-2 led to major economic and health challenges worldwide.
Revealing host genes essential for infection by multiple variants of SARS-CoV-2 can provide …

An incomplete understanding of the molecular mechanisms behind impairment of lung
pathobiology by COVID-19 complicates its clinical management. In this study, we analyzed …

Idiopathic interstitial pneumonias (IIPs) comprise a heterogeneous group of rare lung
parenchyma disorders with high morbidity and mortality, which can occur at all ages. In …

Pulmonary surfactant is a complex fluid that comprises phospholipids and four proteins (SP-
A, SP-B, SP-C, and SP-D) with different biological functions. SP-B, SP-C, and SP-D are …

Interstitial lung disease (ILD) in children (chILD) is a heterogeneous group of rare respiratory
disorders that are mostly chronic and associated with high morbidity and mortality. The …

Genetic factors play an important role in chILD, and the ongoing development of novel
technologies will rapidly broaden the genetic landscape of chILD. Therefore, in the coming …

Background Air pollution is a large environmental health hazard whose exposure and health
effects are unequally distributed among individuals. This is, at least in part, due to gene …

The human SFTPA1 and SFTPA2 genes encode the surfactant protein A1 (SP-A1) and SP-
A2, respectively, and they have been identified with significant genetic and epigenetic …