The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

Atherosclerosis, a chronic cardiovascular disease caused by plaque development in
arteries, remains a leading cause of morbidity and mortality. Atherosclerotic plaques are …

Aims Novel therapies are needed for recurrent pericarditis, particularly when corticosteroid
dependent and colchicine resistant. Based on limited data, interleukin-1 blockade with …

Background Enhanced inflammation may lead to exercise intolerance in heart failure with
preserved ejection fraction. The aim of the current study was to determine whether IL …

Objectives: The causative agent for coronavirus disease 2019, severe acute respiratory
syndrome coronavirus 2, appears exceptional in its virulence and immunopathology. In …

Purpose Cardiovascular disease (CVD) is the leading cause of death worldwide. The
current CVD therapeutic drugs require long-term treatment with high doses, which increases …

Cytokines in cardiac tissue plays a key role in progression of cardiometabolic diseases and
cardiotoxicity induced by several anticancer drugs. Interleukin-1β is one on the most studied …

The initial events in cardiogenic pulmonary edema involve hemodynamic pulmonary
congestion with high capillary pressures. This causes increased fluid transfer out of …

Muscone is the main active monomer of traditional Chinese medicine musk. Previous
studies have reported a variety of beneficial effects of muscone. However, the effects of …

Atherosclerosis, the leading cause of death worldwide, is responsible for≈ 17.6 million
deaths globally each year. Most therapeutic drugs for atherosclerosis have low delivery …