Centromeres are essential for chromosome inheritance and genome stability. Centromeric
proteins, including the centromeric histone centromere protein A (CENP-A), define the site of …

Mitosis ensures equal genome segregation in the eukaryotic lineage. This process is
facilitated by microtubule attachment to each chromosome via its centromere. In …

In mammals, CENP-A, a histone H3 variant found in the centromeric chromatin, is critical for
faithful chromosome segregation and genome integrity maintenance through cell divisions …

Centromeres are essential genetic elements that enable spindle microtubule attachment for
chromosome segregation during mitosis and meiosis. While this function is preserved …

CENP-A is a histone variant that replaces conventional H3 in nucleosomes of functional
centromeres. We report here, from reconstitutions of CENP-A-and H3-containing …

Abstract CENP-A and CENP-B are major components of centromeric chromatin. CENP-A is
the histone H3 variant, which forms the centromere-specific nucleosome. CENP-B …

The centromere of the maize (Zea mays) B chromosome contains several megabases of a B-
specific repeat (ZmBs), a 156-bp satellite repeat (CentC), and centromere-specific …

Neocentromeres are ectopic sites where new functional kinetochores assemble and permit
chromosome segregation. Neocentromeres usually form following genomic alterations that …

The centromere is an essential functional domain responsible for the correct inheritance of
eukaryotic chromosomes during cell division. Eukaryotic centromeres include the highly …

Maintaining genome stability is essential to an organism's health and survival. Breakdown of
the mechanisms protecting the genome and the resulting genome instability are an …