Pancreatic β-cell failure, clinical implications, and therapeutic strategies in type 2 diabetes

D Cui, X Feng, S Lei, H Zhang, W Hu, S Yang… - Chinese Medical …, 2024 - mednexus.org
Pancreatic β-cell failure due to a reduction in function and mass has been defined as a
primary contributor to the progression of type 2 diabetes (T2D). Reserving insulin-producing …

Molecular Docking Integrated with Network Pharmacology Explores the Therapeutic Mechanism of Cannabis sativa against Type 2 Diabetes

JM Guzmán-Flores, V Pérez-Vázquez… - Current Issues in …, 2023 - mdpi.com
The incidence of type 2 diabetes (T2D) is rising, and finding new treatments is important. C.
sativa is a plant suggested as a potential treatment for T2D, but how it works needs to be …

Does diabetes mellitus impair the clinical results of total knee arthroplasty under enhanced recovery after surgery?

S Li, H Si, S Zhang, J Xu, Y Liu, B Shen - Journal of Orthopaedic Surgery …, 2023 - Springer
Background Diabetes mellitus (DM) and osteoarthritis (OA) are common diseases that are
predicted to increase in prevalence, and DM is a risk factor for OA progression and has a …

Diabetes mellitus in patients with acromegaly: pathophysiology, clinical challenges and management

D Esposito, CL Boguszewski, A Colao… - Nature Reviews …, 2024 - nature.com
Acromegaly is a rare endocrine disease caused by hypersecretion of growth hormone, most
commonly arising due to a pituitary adenoma. Diabetes mellitus is a common complication …

Integrating glycolysis, citric acid cycle, pentose phosphate pathway, and fatty acid beta-oxidation into a single computational model

SM Kloska, K Pałczyński, T Marciniak, T Talaśka… - Scientific Reports, 2023 - nature.com
The metabolic network of a living cell is highly intricate and involves complex interactions
between various pathways. In this study, we propose a computational model that integrates …

Saponin monomers: Potential candidates for the treatment of type 2 diabetes mellitus and its complications

L Zhang, S He, L Liu, J Huang - Phytotherapy Research, 2024 - Wiley Online Library
Type 2 diabetes mellitus (T2DM), a metabolic disease with persistent hyperglycemia
primarily caused by insulin resistance (IR), has become one of the most serious health …

Cluster analysis of patient characteristics, treatment modalities, renal impairments, and inflammatory markers in diabetes mellitus

M Cojic, A Klisic, A Sahmanovic, N Petrovic, G Kocic - Scientific Reports, 2024 - nature.com
Type 2 diabetes mellitus (T2DM) is caused by an interplay of various factors where chronic
hyperglycemia and inflammation have central role in its onset and progression. Identifying …

[HTML][HTML] Harnessing beta cell regeneration biology for diabetes therapy

S Bourgeois, S Coenen, L Degroote, L Willems… - Trends in Endocrinology …, 2024 - cell.com
The pandemic scale of diabetes mellitus is alarming, its complications remain devastating,
and current treatments still pose a major burden on those affected and on the healthcare …

Incident infection risks depending on oral antidiabetic exposure in insulin-treated type 2 diabetes patients

S Park, J Jeong, Y Woo, YJ Choi, S Shin - Scientific Reports, 2023 - nature.com
Abstract Dipeptidyl peptidase-4 inhibitors (DPP4is) and sodium glucose cotransporter-2
inhibitors (SGLT2is) have been speculated to have a potential to increase infection risks in …

Skeletal muscle overexpression of sAnk1. 5 in transgenic mice does not predispose to type 2 diabetes

E Pierantozzi, L Raucci, S Buonocore, EM Rubino… - Scientific Reports, 2023 - nature.com
Genome-wide association studies (GWAS) and cis-expression quantitative trait locus (cis-
eQTL) analyses indicated an association of the rs508419 single nucleotide polymorphism …