Involvement of substance P and the NK-1 receptor in human pathology
M Muñoz, R Coveñas - Amino acids, 2014 - Springer
The peptide substance P (SP) shows a widespread distribution in both the central and
peripheral nervous systems, but it is also present in cells not belonging to the nervous …
peripheral nervous systems, but it is also present in cells not belonging to the nervous …
Schwann cells and trigeminal neuralgia
JY Liao, TH Zhou, BK Chen, ZX Liu - Molecular pain, 2020 - journals.sagepub.com
Schwann cells are components of the peripheral nerve myelin sheath, which supports and
nourishes axons. Upon injury of the trigeminal nerve, Schwann cells are activated and …
nourishes axons. Upon injury of the trigeminal nerve, Schwann cells are activated and …
The molecular and pharmacological mechanisms of HIV-related neuropathic pain
S Hao - Current neuropharmacology, 2013 - ingentaconnect.com
Infection of the nervous system with the human immunodeficiency virus (HIV-1) can lead to
cognitive, motor and sensory disorders. HIV-related sensory neuropathy (HIV-SN) mainly …
cognitive, motor and sensory disorders. HIV-related sensory neuropathy (HIV-SN) mainly …
Endogenous inflammatory mediators produced by injury activate TRPV1 and TRPA1 nociceptors to induce sexually dimorphic cold pain that is dependent on TRPM8 …
C Yang, S Yamaki, T Jung, B Kim, R Huyhn… - Journal of …, 2023 - Soc Neuroscience
The detection of environmental temperatures is critical for survival, yet inappropriate
responses to thermal stimuli can have a negative impact on overall health. The physiological …
responses to thermal stimuli can have a negative impact on overall health. The physiological …
NK-1 antagonists and itch
S Ständer, TA Luger - Pharmacology of Itch, 2015 - Springer
Substance P (SP) is an important mediator of pro-inflammatory mechanisms in the skin. It
targets multiple cells such as keratinocytes, mast cells, and fibroblasts which are involved in …
targets multiple cells such as keratinocytes, mast cells, and fibroblasts which are involved in …
Diverse role of biological plasticity in low back pain and its impact on sensorimotor control of the spine
Pain is complex. It is no longer acceptable to consider pain solely as a peripheral
phenomenon involving activation of nociceptive neurons. The contemporary understanding …
phenomenon involving activation of nociceptive neurons. The contemporary understanding …
Cold hypersensitivity increases with age in mice with sickle cell disease
KJ Zappia, SR Garrison, CA Hillery, CL Stucky - PAIN®, 2014 - Elsevier
Sickle cell disease (SCD) is associated with acute vaso-occlusive crises that trigger painful
episodes and frequently involves ongoing, chronic pain. In addition, both humans and mice …
episodes and frequently involves ongoing, chronic pain. In addition, both humans and mice …
[HTML][HTML] Hemokinin-1 gene expression is upregulated in trigeminal ganglia in an inflammatory orofacial pain model: Potential role in peripheral sensitization
A large percentage of primary sensory neurons in the trigeminal ganglia (TG) contain
neuropeptides such as tachykinins or calcitonin gene-related peptide. Neuropeptides …
neuropeptides such as tachykinins or calcitonin gene-related peptide. Neuropeptides …
Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury
PW Fisher, Y Zhao, MC Rico, VS Massicotte… - Journal of cell …, 2015 - Springer
Key clinical features of cumulative trauma disorders include pain, muscle weakness, and
tissue fibrosis, although the etiology is still under investigation. Here, we characterized the …
tissue fibrosis, although the etiology is still under investigation. Here, we characterized the …
Trigeminal neuroplasticity underlies allodynia in a preclinical model of mild closed head traumatic brain injury (cTBI)
Post-traumatic headache (PTH) following TBI is a common and often persisting pain
disability. PTH is often associated with a multimodal central pain sensitization on the skin …
disability. PTH is often associated with a multimodal central pain sensitization on the skin …