Integrins are adhesion receptors that allow cells to sense and respond to
microenvironmental signals encoded by the extracellular matrix. They are crucial for the …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Extracellular matrix (ECM) molecules are responsible for structural and biochemical support,
as well as for regulation of molecular signalling and tissue repair in many organ structures …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

Summary Type 1 (T1D) or type 2 diabetes (T2D) are caused by a deficit of functional insulin-
producing β cells. Thus, the identification of β cell trophic agents could allow the …

This is the third in a series of Perspectives on intracellular signaling pathways coupled to
proliferation in pancreatic β-cells. We contrast the large knowledge base in rodent β-cells …

Loss of β cell identity, the presence of polyhormonal cells, and reprogramming are emerging
as important features of β cell dysfunction in patients with type 1 and type 2 diabetes. In this …

This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …

The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

The extracellular matrix (ECM) critically affects β cell functions via integrin activation. But
whether these ECM actions drive the spatial organization of β cells, as they do in epithelial …