Highlights•Dynamic shifts in cell polarity help shape the early pancreatic epithelium.•
Apicobasal polarity and planar cell polarity (PCP) play roles in pancreas development and …

Objective: A potential solution for islet transplantation and drug discovery vis-à-vis treating
diabetes is the production of functional islets in a three-dimensional extracellular matrix …

The development and function of epithelia depend on the establishment and maintenance of
cell-cell adhesion and intercellular junctions, which operate as mechanosensor hubs for the …

The pancreatic islet of Langerhans is a multicellular system that relies on cell–cell
interaction and communication for its function. The most abundant cells in the islets are …

β1-integrin is a key receptor that regulates cell-ECM interactions and is important in
maintaining mature beta-cell functions, including insulin secretion. However, there is little …

Background. White adipose tissue (WAT) is a candidate transplantation site for islets.
However, the mechanism of islet engraftment in WAT has not been fully investigated. In this …

Shortcomings in cell-based therapies for patients with diabetes have been revealed to be, in
part, a result of an improper extracellular matrix (ECM) environment. In vivo, pancreatic islets …

The shortage of donor islets is a significant obstacle for widespread clinical application of
pancreatic islet transplantation. To investigate whether adipose tissue-derived …

NK cells play an important role in antiviral resistance. The integrin α2, which dimerizes with
integrin β1, distinguishes NK cells from innate lymphoid cells 1 and other leukocytes …

SEL1L, a component of the endoplasmic reticulum associated degradation (ERAD)
pathway, has been reported to regulate the (i) differentiation of the pancreatic endocrine and …