The co-culturing of insulinoma and islet-derived endothelial cell (iEC) lines results in the
spontaneous formation of free-floating pseudoislets (PIs). We previously showed that iEC …

Tissue regeneration is the ultimate treatment for many degenerative diseases, however,
repair and regeneration of damaged organs or tissues remains a challenge. Previously, we …

Glucose homeostasis relies on tightly regulated insulin secretion from pancreatic beta-cells,
and its loss in diabetes is associated with the dysfunction of these cells. Beta-cells reside in …

The β1 integrin subunit contributes to pancreatic beta cell growth and function through
communication with the extracellular matrix (ECM). The effects of in vitro and in vivo β1 …

Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which
deposit connective tissue, leading to obliteration of the function of the underlying organ. The …

Highlights•Adhesion receptors expressed by islets include integrins, cadherins and
adhesion GPCRs.•Endogenous ligands of adhesion receptors are mainly proteins of the …

The human fetal pancreas expresses a variety of extracellular matrix (ECM) binding
receptors known as integrins. A provisional ECM protein found in blood clots that can bind to …

Human pluripotent stem cells (hPSCs) differentiation into pancreatic endocrine cells has
been proposed as a strategy to generate surrogate islets to treat type 1 diabetes (T1D) …

Diabetes is a metabolic disease of epidemic proportions, which involves loss of function
and/or viability of pancreatic islet cells. Current therapies consist of whole pancreas …

Background Definitive endoderm (DE) gives rise to the respiratory apparatus and digestive
tract. Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE …