The N3 and N6 long chain polyunsaturated fatty acids (LCPUFA) docosahexaenoic acid
(DHA) and arachidonic acid (AA) are essential for proper neurodevelopment in early life …

The precise temporal control of uterine contractility is essential for the success of pregnancy.
For most of pregnancy, progesterone acting through genomic and non-genomic …

There is growing evidence that long-chain polyunsaturated fatty acids (LCPUFAs) are of
importance for normal brain development. Adequate supply of LCPUFAs may be particularly …

Estrogens are thought to promote labor by increasing the expression of pro-contraction
genes in myometrial cells. The specific estrogen receptors ((ERs: ERa and ERb (also known …

Despite the extensive research during the last six decades the fundamental questions
concerning the role of steroids in the initiation of human parturition and origin and function of …

This study addresses the question of whether changes in the biosynthesis and metabolism
of neuroactive pregnanolone isomers (PIs) might participate in the timing of parturition in …

The pregnanolone isomers (PI) allopregnanolone (3α-hydroxy-5α-pregnan-20-one),
pregnanolone (3α-hydroxy-5β-pregnan-20-one), isopregnanolone (3β-hydroxy-5α-pregnan …

We examined the effects of estradiol (E2), 4-tert-octylphenol (OP), and bisphenol A (BPA) on
uterine contractions in immature rats. The expression and localization of contraction …

Pregnanolone isomers (PIs) and their polar conjugates (PICs) modulate ionotropic receptors
such as γ-aminobutyric acid or pregnane X receptors. Besides, brain synthesis, PI …

Introduction We have previously demonstrated that oxytocin (OT) and endothelin-1 (ET-1)
peripherally regulate epididymal motility in an estrogen-dependent way. Because RhoA/Rho …