Abstract Myotonic dystrophy type 1 (DM1) is caused by a CTG repeat expansion in the
DMPK gene. Expression of pathogenic expanded CUG repeat (CUGexp) RNA causes …

Myotonic dystrophy type 1 (DM1) is a neuromuscular disease caused by the expansion of a
CTG repeat in the DMPK gene and characterised by progressive skeletal muscle weakness …

Skeletal muscle formation is a multi-step process that is governed by complex networks of
transcription factors. The regulation of their functions is in turn multifaceted, including several …

Cardiovascular disease (CVD) is a major cause of mortality and hospitalization worldwide.
Several risk factors have been identified that are strongly associated with the development …

Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by a non-coding CTG
repeat expansion in the DMPK gene. This mutation generates a toxic CUG RNA that …

Alternative splicing is an essential post-transcriptional process to generate multiple
functional RNAs or proteins from a single transcript. Progress in RNA biology has led to a …

Despite significant advances in understanding of the causes of and treatment of myocardial
infarction (MI) in recent years, morbidity and mortality is still high. The aim of this study was …

Myotonic Dystrophy (DM), one of the most common neuromuscular disorders in adults,
comprises two genetically distinct forms triggered by unstable expanded repeats in non …

Abstract Myotonic Dystrophy type 1 (DM1) is caused by an expansion of CUG repeats in
DMPK mRNAs. This mutation affects alternative splicing through misregulation of RNA …

Splicing aberrations induced as a consequence of the sequestration of muscleblind-like
splicing factors on the dystrophia myotonica protein kinase transcript, which contains …